Никотинамид рибозид хлорид прах NR-Cl

Никотинамидрибозидхлорид% 3bНикотинамидB-DRibosideChloride(WX900111);НикотинамидRiboside. Cl;Никотимидерибозидхлорид;Пиридиний,3-(аминокарбонил)-1- -D-рибофуранозил-,chloride(1:1);3-carbamoyChemicalbookl-1-((2R,3R,4S,5R)-3,{{{{{{{}{.7b.p·7 15}}dihydroxy{-5-(хидроксиметил)тетрахидрофуран-2-yl)пиридин-1-iumchloride;3-Carbamoyl-1-( -D-рибофуранозил)пиридиниев хлорид;3-Carbamoyl{{24}% 7dbeta-D-рибофуранозилпиридиниев хлорид

CAS number: 23111-00-4

Молекулярна формула% 3a C11H15ClN2O5

Молекулярно тегло: 290.7

EINECS No.: 200-184-4

Съхранение условия% 3a underinertgas (азот или аргон) at% 7b% 7b0% 7d% 7d степен

Разтворимост: Solubleto1Chemicalbook00mMinDMSOandto100mMinwater

Формуляр: плътен

Цвят:Бял

Стабилност:Хигроскопичен

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Въведение:

Никотинамид рибозид е прекурсор на никотинамид аденин динуклеотид (NAD) и представлява a източник на витамин B3. Последни изследвания има показа че нов здраве ползи може да бъде получен от консумиране по-високи количества на никотинамид рибозид от естествено намерени в храни. Никотинамид мононуклеотид играе и важна роля в енергията поколение на човешки клетки. Той участва в синтеза на NAD (никотинамид аденин динуклеотид % 2c an важно коензим за клетка енергия преобразуване) в клетки.

Опишете:

Никотинамид рибозид хлорид% 2c a кристална форма на никотинамид рибозид (NR) хлорид известен като NIAGEN% 2c е общо признат като безопасен (GRAS) за употреба в храна и диетични добавки. Никотинамид рибозид е а източник на витамин B3 (ниацин) % 2c което подобрява оксидативен метаболизъм и предотвратява метаболитни аномалии причинени от а високо съдържание на мазнини диета. Никотинамид рибозид е а новооткрито NAD (NAD% 2b) провитамин.

Използвай:

Nicotinamide riboside has been implicated in increasing tissue NAD concentration and inducing insulin sensitivity and enhancing sirtuin function. Its ability to increase NAD production suggests that nicotinamide riboside may also improve mitochondrial health, stimulate mitochondrial function, and induce the production of new mitochondria. Other studies using nicotinamide riboside in Alzheimer's disease models have shown that this molecule is bioavailable to the brain and may provide neuroprotection by stimulating brain NAD synthesis. Additionally, a 2012 study observed that mice fed a high-fat diet supplemented with nicotinamide riboside experienced a 60 percent reduction in weight gain compared to mice fed the same high-fat diet without nicotinamide riboside. Nicotinamide riboside chloride (3-carbamoyl-1-[(2R,3R,4S5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-pyridine -1-ium chloride; also known as 1-( -D-ribofuranosyl)nicotinamide chloride) is a known salt form of nicotinamide riboside, although useful salts of nicotinamide riboside and its chloride salts exist properties (e.g. in pharmaceuticals or nutritional supplements), but usually need improvement.

производство метод:

The residue was transferred back to the 20 L reactor with 7.5 L of methanol. An ice bath was applied to the reactor to adjust the internal temperature to 3 degree . On the other hand, 3.75 L (3.75 mol) of 1M NaOCH3 dissolved in methanol was cooled to 3 degree , and then this solution was added to the reactor over 10 minutes. During the addition, the internal temperature was kept below 5 degree . After the addition was complete, the reaction mixture was stirred for 30 minutes, then 1.25 L (3.75 mol) of 3M HCl was added slowly, keeping the internal temperature below 5 degree . At the end of the addition of HCl, the pH=3. Solvent was removed under vacuum. (For convenience, the partially concentrated solution can be stored at 4 degree for up to 48h). After complete concentration, the residue can be stored at -20 degree for up to 18h. To remove residual methanol, the evaporation residue was dissolved in water and concentrated under vacuum (3x1 L). The residue was taken up in 5 L of water and the pH was adjusted to 4 with 2M NaOH(aq). Sodium chloride (NaCl) was added to the solution, and the mixture was stirred at room temperature until the NaCl was saturated, leaving about 5 g of undissolved NaCl. The saturated solution was extracted with tetrahydrofuran (THF, 3x5L). The aqueous layer was monitored by 1H NMR to confirm that acetic acid had been removed after extraction was complete. The aqueous phase was adjusted to pH=6-7 with 2M NaOH(aq), then extracted with THF (4x5L). The aqueous layer was monitored by 1H NMR to confirm that residual nicotinamide was <5 mol% relative to nicotinamide riboside. The absence of triflate in the aqueous layer was also confirmed using 19FNMR. The aqueous layer was then concentrated under vacuum to remove 2.5 L of water. The residual suspension was diluted with 5 L of ethanol, filtered, and the salt precipitate was washed with 2.5 L of ethanol. The combined filtrate and washings were concentrated in vacuo to a thick oil. This was stirred with 1.5 L of methanol, the precipitate was filtered, and the solution was concentrated under vacuum. The residue was stirred with an additional 1.5 L of methanol, the precipitate was filtered and the solution concentrated in vacuo. The residue was stirred with a third 1.5 L portion of methanol, the precipitate was filtered and the solution concentrated in vacuo to give 385 g of an orange-red oil. It was confirmed by 1H NMR that the amount of residual methanol was 34 g, and the crude product yield was 351 g (77%). THF extraction was used to remove most of the excess nicotinamide.

Биологична активност:

Никотинамид рибозид хлорид (NIAGEN) е хлорид сол форма на никотинамид рибозид (NR) . NR е а производно на витамин B3 и може да бъде използва се като a прекурсор на NAD или NAD% 2b. NIAGEN е общо признат като безопасен за употреба в храна в Съединените щати

цел:SIRT1SIRT3

In vitro проучвания:

НикотинамидрибозидХлорид ({{0}}.5nM;24hours)намалява статуса на ацетилиране на Ndufa9andSOD2.НикотинамидрибозидХлорид увеличава вътреклетъчните и митохондриалните NAD+contentinC2C12,Hepa1.6,andHEK293cellsinaконцентрация-dependentmanneratconcentrationsrangeingfrom1-1000μM.NicotinamideribosidechlorideboostsNADtorestoreantiviralpoly(ADP-ribose)polymerase(PARP)functionstosupportinnateimmunityforcoronavirus(CoVs)% 2cacauseofCOVID-19. WesChemicalbookternBlotAnalysisCellLine:HEK293TcellsКонцентрация:0.5nMIncubationTime:24hoursResult:ReducedtheacetylationstatusofNdufa9andSOD2.

ChronicNicotinamideribosideChloride(p.o.;400mg/kg/day;for16weeks)supplementationincreasesplasmaandintracellularNAD+contentinatissue-specificway. AnimalModel:10-week-oldC57Bl/6JmiceDosage:400mg/kgAdministration:PO;daily;for16weeksResult:IncreaseplasmaandintracellularNAD+contentinatissue-specificway.

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